The 73rd Annual Meeting
March 23-25, 2000
YokohamaChairman: Taku Nagao
Abstracts
Committee
Masamitsu Iino (Grad. School of Med., The Univ. of Tokyo)
Kunio Ishii (Kitasato Univ., School of Pharm. Sci.)
Hideaki Karaki (Grad. School of Agri. & Life Sci., The Univ. of Tokyo)
Koichiro Kawashima (Kyoritsu Coll. Pharmacy)
Norio Matsuki (Grad. School of Pharm. Sci., The Univ. of Tokyo)
Miwa Misawa (Hoshi Univ., School of Pharmacy)
Masayoshi Mishina (Grad. School of Med., The Univ. of Tokyo)
Hideki Ono (Fac. Pharm. Sci., Science Univ. of Tokyo)
Shingo Yano (Grad. School of Pharm. Sci., Chiba Univ.)
Secretariat
Tetsuro Urushidani
Laboratory of Pharmacology and Toxicology
Graduate School of Pharmaceutical Sciences
The University of Tokyo
Tokyo, 113-0033
Phone: 03-5841-4860
Fax: 03-5841-4867
E-mail: toxicol@mol.f.u-tokyo.ac.jp
Contents
Invited Lecture
IL The pharmacology of cardioprotection against ischemia: mitochondrial
channels as novel targets
Eduardo Marban.........2P
Special Lectures
SL-1 Molecular mechanism of drug transport
Hitoshi Endou......... 3P
SL-2 Physiology and pathophysiology of prostanoids; lessons from receptor-knockout
mice
Shuh Narumiya......... 3P
SL-3 Roles and cross talk of inflammatory mediators
Sachiko Oh-ishi........ 3P
SL-4 A new functional approach toward anti-Alzheimer disease therapy
Ikuo Nishimoto........ 3P
SL-5 Pharmacology of glutamate receptors
Haruhiko Shinozaki........ 4P
SL-6 Transcriptional control by nuclear steroid hormone receptors
Shigeaki Kato........ 4P
SL-7 Calcium channels and pain
Tsutomu Tanabe........ 4P
SL-8 Molecular characterization of low voltage-activated T-type calcium
channels
Edward Perez-Reyes....... 4P
Award Lectures
AL-1 Functional involvement of diazepam binding inhibitor (DBI)
in drug dependence and its withdrawal
Masashi Katsura......... 5P
AL-2 Molecular identification of an organic anion transporter (OAT) family
and its role in the transmembrane transport of anionic drugs
Takashi Sekine......... 5P
AL-3 Possible mechanisms in learning and memory formation by using mutant
mice
Yukihiro Noda......... 5P
Symposia
S1 Transporters in drug development
Yoshikatsu Kanai and Ken-ichi Inui ....... 8P
S2 Visualization of cell signals and its impact on pharmacology
Masamitsu Iino and Naoaki Saito ....... 9P
S3 New aspects of the regulation of smooth muscle tone and contraction
Masaatu K. Uchida and Kazuhiro Kohama ........ 10P
S4 Dynamic control of cell-to-cell signaling in the central nervous system
network: an up-date
Fusao Kato and Toshihiko Momiyama ........ 11P
S5 Recent progress on the drugs targeting ion channels
Yoshihisa Kurachi and Koki Shigenobu ....... 13P
S6 Repair and regeneration of bone and cartilage: are they possible?
Hiroyuki Kawashima and Masaki Noda ........ 14P
S7 Pharmacological aspects of HMG-CoA reductase inhibitors
Kazuo Ichihara and Kenji Matsuyama ........ 15P
S8 New development in pharmacogenomics
Toshio Tanaka and Yoshiji Fujita ........ 17P
S9 Animal models of ocular disease for drug development
Kazutaka Momose and Hajime Yasuhara ........ 18P
S10 Microglia and neuronal functions
Kenji Yamamoto and Akemichi Baba ....... 19P
S11 Roles of mitochondrial Ca2+ signaling and membrane potential
in cellular functions
Takeshi Katsuragi and Yuji Imaizumi ....... 20P
S12 Creation of excellent medicines on the basis of drug receptor studies:
approaches from molecular modeling and genetic engineering
Yasushi Ohizumi and Takafumi Nagatomo ....... 22P
S13 Pharmacology of endocrine-disrupting chemicals
Norio Matsuki and Taisen Iguchi ........ 23P
S14 Molecular structure and function of mechanosensor mechanisms: an
alternative prospect for the development of new drugs
Koichi Nakayama and Hisayuki Ohata ....... 24P
S15 Application of pharmacological studies employing in vivo bio-imaging
technologies
Kazuo Honda and Kunio Ishii ........ 25P
S16 Is chymase a new target for drug development?
Mizuo Miyazaki and Toshiaki Tamaki ........ 26P
S17 Extraneuronal cholinergic systems
Koichiro Kawashima and Yasuyuki Nomura ........ 27P
S18 Perspectives on the development of drugs for Alzheimer's disease
Toshitaka Nabeshima and Hiroshi Watanabe ........ 28P
S19 Pharmacology education: innovative proposals from several fields
Masatoshi Tanaka and Miwa Misawa ........ 30P
S20 Pathophysiological aspects of the gastrointestinal tract in autacoid-
and hormone-related gene-deficient mice
Susumu Okabe and Takehiko Watanabe ........ 31P
S21 The front of signal-transduction and modulation of pain
Kazuhide Inoue and Masamichi Satoh ........ 33P
S22 Mechanisms underlying diabetic complications and the molecular biological
approach for their treatment
Katsuo Kamata and Koji Takeuchi ........ 35P
S23 Gene therapy: its present status and future direction
Teruhiko Toyo-oka and Yasufumi Kaneda ....... 36P
S24 5-HT4 receptors in the brain and periphery
Mitsuhiro Yoshioka and Masaru Minami ........ 36P
S25 Molecular pharmacology of opioids and their receptors
Tetsuo Oka and Henry I. Yamamura ........ 38P
Free Communications
Oral Sessions
Biogenic Active Substances .......... O-12-17, O-188-194
Receptors and Channels.......... O-83-86, O-153-166, O-209-222, O-274-277
Signal Transduction .......... O-1-11, O-51-56, O-118-124
Biochemical Pharmacology .......... O-237-243
Molecular Pharmacology .......... O-244-251
Molecular Biology .......... O-286-292
Cardiovascular Pharmacology
Endothelium.......... O-37-50, O-87-98
Cardiac Functions .......... O-293-307
Vascular Smooth Muscles .......... O-195-208
Blood Pressure and Circulation .......... O-139-152
Autonomic Nervous System Pharmacology .......... O-57-61
Central Nervous System Pharmacology
Analgesia .......... O-167-173
Dependence and Tolerance .......... O-174-180
Neuropharmacology .......... O-68-74, O-252-273
Behavioral Pharmacology .......... O-125-131
Neurotransmitters .......... O-132-138
Memory and Learning .......... O-75-82
Respiratory Pharmacology.......... O-278-285
Renal Pharmacology.......... O-111-117
Gastrointestinal Pharmacology .......... O-99-110
Smooth Muscle Pharmacology......... O-223-236
Bone/Dental Pharmacology .......... O-18-23
Endocrine Pharmacology.......... O-62-67
Immunopharmacology and Inflammation.......... O-24-36, O-181-187
Poster Sessions
Biogenic Active Substances .......... P-1-33
Receptors and Channels.......... P-34-91
Signal Transduction .......... P-92-115
Biochemical Pharmacology .......... P116-137
Molecular Pharmacology .......... P-138-148
Molecular Biology .......... P-326-332
Cardiovascular Pharmacology ......... P-256-264
Endothelium.......... P-265-293
Cardiac Functions .......... P-294-325
Vascular Smooth Muscles .......... P-333-366
Blood Pressure and Circulation .......... P-367-404
Autonomic Nervous System Pharmacology .......... P-405-422
Central Nervous System Pharmacology
Analgesia .......... P-149-179
Dependence and Tolerance .......... P-180-187
Neuropharmacology .......... P-188-255
Behavioral Pharmacology .......... P-423-443
Neurotransmitters .......... P-444-457
Memory and Learning .......... P-458-481
Neurochemistry ......... P-482-497
Neurotrophic Factors ......... P-498-503
Respiratory Pharmacology ......... P-504-515
Renal Pharmacology ......... P-516-529
Gastrointestinal Pharmacology .......... P-530-551
Smooth Muscle Pharmacology .......... P-552-568
Bone and Dental Pharmacology ......... P-563-581
Endocrine Pharmacology ......... P-582-594
Clinical Pharmacology ......... P-595-598
Immunopharmacology and Inflammation .......... P-599-622
Chemotherapy ......... P-623-627
Differentiation ......... P-628-630
Toxicology..........P-631-645
Author Index..........2
Subject Index ..........30
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