Jpn. J. Pharmacol. 76 Supplement I (1998)

The 71st Annual Meeting

March 23-26, 1998
Takaragaike, Kyoto

President: Noboru Toda


Abstracts

Committee

Youichi Abe (Dept. of Pharmacol., Kagawa Med. Sch.)
Akinori Akaike (Dept. of Pharmacol., Kyoto Univ. Faculty of Pharm.)
Munekazu Gemba (Dept. of Pharmacol., Osaka Univ. of Pharm. Sci.)
Hiroshi Iwao (Dept. of Pharmacol., Osaka City Univ. Med. Sch.)
Yasuo Matsumura (Dept. of Pharmacol., Osaka Univ. of Pharm. Sci.)
Mizuo Miyazaki (Dept. of Pharmacol., Osaka Med. College)
Tomio Okamura (Dept. of Pharmacol., Shiga Univ. Med. Sci.)
Masamichi Satoh(Dept. of Mol. Pharmacol., Kyoto Univ. Faculty of Pharm.)
Toshiaki Tamaki (Dept. of Pharmacol., The Tokushima Univ. Sch. of Med.)

Secretariat

Tomio Okamura, Kazuhide Ayajiki, Hideyuki Fujioka, Etsuko Kumagai
Department of Pharmacology
Shiga University of Medical Science
Seta, Ohtsu 520-2192, Shiga
Phone: 077-548-2181 Fax: 077-548-2183

Contents

Special Lectures
SL-1 Scenarios for neuroscience in the 21st century
Masao Ito......... 3P

SL-2 Adventures in Research: From prostacyclin to nitric oxide
Salvador Moncada......... 3P

SL-3 New molecular biological approaches to new angiotensin receptor signaling mechanisms
Tadashi Inagami......... 3P

Presidential Lecture
PL New concepts of parasympathetic vasomotor innervation
Noboru Toda......... 4P

Educational Lectures
EL-1 Endothelin
Katsutoshi Goto......... 5P

EL-2 Adrenomedullin
Kazuo Kitamura......... 5P

EL-3 Natriuretic peptides
Mitsuhide Naruse......... 5P

EL-4 Cardiovascular chymase
Hideki Okunishi......... 5P

Award Lectures
AL-1 Characterization and functional analysis of a novel cell adhesion molecule, gicerin
Eiichi Taira......... 6P

AL-2 Novel approach to treatment of cardiovascular diseases using an endothelin receptor antagonist
Takashi Miyauchi......... 6P

AL-3 Glutamate receptor and synaptic plasticity
Yasunori Hayashi......... 6P

Symposia
OS The pharmacological contribution to clinical pharmacy - A view into the 21st century
Matao Sakanashi and Takeshi Miyata......... 9P

S1 Molecular genetics of Alzheimer disease and therapeutic window
Chikako Tanaka and Yasuo Ihara......... 11P

S2 Endothelial control of blood vessel
Hideaki Karaki and Kazuyoshi Kurahashi......... 12P

S3 Pathophysiological role of signal transduction system
Hiroshi Iwao and Gozo Tsujimoto......... 14P

S4 Molecular pharmacology of ATP-sensitive K+ channels
Toshihiko Iijima and Yoshihisa Kurachi......... 15P

S5 Molecular pharmacology of orphan receptors and their endogenous ligands
Hiroshi Ueda and Yoshihiro Nakata......... 17P

S6 Neuroprotection: a possible new approach for therapy in neurodegenerative disorders
Akinori Akaike and Shun Shimohama ......... 19P

S7 Tachykinin NK1 receptor antagonists and drug development
Masaru Minami and Norio Matsuki......... 20P

S8 Molecular mechanisms of drug transport
Hitoshi Endou and Yuichi Sugiyama......... 22P


S9 Recent advance in ATP receptor research
Hironori Nakanishi and Kazuhide Inoue......... 23P

S10 Recent progress in basic NO research
Tomio Okamura and Toshio Nakaki......... 25P

S11 Regulation of Cl- transport - Insights into the therapeutic applications
Chiyoko Inagaki and Tadashi Imai......... 26P

S12 Important aspects of drugs in the 21st century
Eishichi Miyamoto and Masamichi Satoh ......... 27P

S13 The role of antisense oligodeoxynucleotides in the pharmacological investigation
Tetsuo Oka and Akira Murakami......... 29P

S14 International collaboration on traditional medicine: What is the Thai narcotic substitute extracted from Mitragyna speciosa leaves?
Hiroshi Watanabe and Kazuo Watanabe......... 31P

S15 New domains of angiotensin research
Mizuo Miyazaki and Masao Endoh......... 32P

S16 Recent progress of cytochrome P450: Genetic polymorphism and pharmacological function of metabolites of endogenous substrates
Yoshihiko Funae and Tetsuya Kamataki......... 33P

S17 Gene expression in the nervous system and its functional analyses
Naomasa Miki and Masaaki Tsuda......... 35P

S18 Knockout mouse studies on prostanoid functions and their implications in drug development
Shuh Narumiya and Sachiko Oh-ishi......... 36P

S19 Intracellular mechanisms of secretory glands
Fumiaki Hata and Hajime Ishida ......... 38P

S20 Presence and future of anti-cerebral infarction agents
Mitsuyoshi Nakajima and Yukito Shinohara ......... 39P

Free Communications
[Oral Sessions]
Cardiovascular Pharmacology

Endothelium / Platelet......... O-1-O-12, O-253-O-258
Vascular Smooth Muscles.......... O-26-O-31, O-130-O-141
Blood Pressure and Circulation.......... O-32-O-37
Cardiac Functions.......... O-142-O-160
Vascular Pharmacology.......... O-332-O-337
Nitric Oxide.......... O-338-O-343

Molecular Biology / Molecular Pharmacology .......... O-13-O-25

Smooth Muscle Pharmacology.......... O-38-O-49

Central Nervous System Pharmacology

Neurochemistry.......... O-50-O-55, O-192-O-203, O-295-O-297
Behavioral Pharmacology.......... O-63-O-74
Neuropharmacology.......... O-112-O-123, O-185-O-191, O-301-O-306
Neurotrophic factor.......... O-161-O-166
Neurotransmitters.......... O-167-O-178
Analgesia / Dependence.......... O-283-O-288, O-298-O-300
Memory and Learning.......... O-289-O-294

Autonomic Nervous System Pharmacology.......... O-56-O-62

Immunopharmacology and Inflammation.......... O-75-O-86, O-241-O-252

Signal Transduction.......... O-87-O-99, O-344-O-350

Renal Pharmacology.......... O-100-O-111

Biochemical Pharmacology.......... O-124-O-129

Respiratory Pharmacology.......... O-179-O-184

Receptors and Channels.......... O-204-O-221, O-259-O-282

Biogenic Active Substances.......... O-222-O-234, O-325-O-331

Endocrine Pharmacology.......... O-235-O-240

Gastrointestinal Pharmacology.......... O-307-O-324

[Poster Sessions]

Biogenic Active Substances.......... P-1-P-19

Biochemical Pharmacology.......... P-20-P-39

Cardiovascular Pharmacology

Cardiovascular function.......... P-40-P-44
Endothelium..........P-45-P-68
Blood Pressure and Circulation.......... P-159-P-203
Vascular Smooth Muscles.......... P-301-P-350
Cardiac Functions.......... P-569-P-614

Central Nervous System Pharmacology

Memory and Learning..........P-69-P-83
Analgesia..........P-84-P-98
Dependence and Tolerance..........P-99-P-106
Neurotransmitters..........P-204-P-231
Central Nervous System..........P-232-P-235
Behavioral Pharmacology..........P-236-P-259
Neuropharmacology..........P-351-P-381, P-471-P-500
Neurochemistry..........P-501-P-518
Neurotrophic factor..........P-519-P-520

Immunopharmacology and Inflammation..........P-107-P-141

Molecular Biology / Molecular Pharmacology..........P-142-P-158

Bone and Dental Pharmacology..........P-260-P-270

Receptors and Channels..........P-271-P-300, P-406-P-438

Clinical Pharmacology..........P-382-P-388

Chemotherapy..........P-389-P-393

Toxicology..........P-394-P-405

Autonomic Nervous System Pharmacology..........P-439-P-455

Renal Pharmacology..........P-456-P-470

Endocrine Pharmacology..........P-521-P-536

Differentiation..........P-537-P-541

Signal Transduction..........P-542-P-568

Respiratory Pharmacology..........P-615-P-624

Gastrointestinal Pharmacology..........P-625-P-659

Smooth Muscle Pharmacology..........P-660-P-686

Author Index..........2

Subject Index ..........20

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