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The 72nd Annual Meeting
March 22-25, 1999
Sapporo, HokkaidoChairman: Morio Kanno
Abstracts
Committee
Yasushi Abiko (Professor emeritus Asahikawa Med. Coll.)
Kazuo Ichihara (Hokkaido Coll. of Pharmacy)
Tetsuya Kamataki (Fac. of Pharmaceu. Sci., Hokkaido Univ.)
Akira Matsumoto (Sch. of Dent., Hokkaido Univ.)
Yoshito Matsumoto (Sch. of Dent., Health Sci. Univ. of Hokkaido)
Masaru Minami (Fac. of Pharmaceu. Sci., Health Sci. Univ. of Hokkaido)
Yoshio Monma (Fac. of Pharmaceu. Sci., Health Sci. Univ. of Hokkaido)
Yoshikazu Nakazato (Grad. Sch. of Vet. Med., Hokkaido Univ.)
Masakazu Nishimura (Univ. of Obihiro Sch. of Vet. Med.)
Yasuyuki Nomura (Grad. Sch. of Pharmaceu. Sci., Hokkaido Univ.)
Hideyo Ohshika (Sapporo Med. Univ. Sch. of Med.)
Hideya Saito (Fac. of Pharmaceu. Sci., Health Sci. Univ. of Hokkaido )
Tetsuro Taneike (Fac. of Vet. Med., Rakuno Gakuen Univ.)
Yukiko Tokumitsu (Grad. Sch. of Pharmaceu. Sci., Hokkaido Univ.)
Mitsuhiro Yoshioka (Hokkaido Univ. Sch. of Med. Hokkaido Univ.)
Secretariat
Yuichi Hattori, Mitsuhiro Yoshioka, Hiroko Togashi, Atsushi Sato, Kanako
Murai
Department of Pharmacology
Hokkaido University School of Medicine
Sapporo 060-8638, Hokkaido
Phone: 011-706-6921, 011-717-2717
Fax: 011-706-7824, 011-717 -2717
E-mail nenkai@med.hokudai.ac.jp
Home page http://www.med.hokudai.ac.jp/nenkai/
Contents
Special Lectures
PL-1 Impact of human genome analysis on the future medicine
Yusuke Nakamura......... 2P
PL-2 The cyclic ADP-ribose-Ca2+ signaling system: molecular
mechanism and
biological significance
Hiroshi Okamoto......... 2P
PL-3 The molecular mechanism of organelle transport: identification and
characterization of kinesin superfamily proteins, KIFs
Nobutaka Hirokawa........ 2P
PL-4 Function of the vascular endothelium and smooth muscle
Tomoh Masaki........ 2P
Chairman Lecture
CL EDHF: another endothelium-derived relaxation
factor
Morio Kanno......... 3P
Educational Lectures
EL-1 A novel aspect of the developments of pharmacology of
experimental ulcer
and gastric secretion
Kazuo Watanabe......... 4P
EL-2 Design of new RNA enzymes and specific cleavage of mRNA
Eiko Ohtsuka......... 4P
EL-3 Signal transduction and calcium
Hideaki Karaki......... 4P
EL-4 Molecular basis of developmental patterning in vostral head
Shinichi Aizawa......... 4P
EL-5 Cell remodeling by glycosyltransferase genes: suppression of cancer
metastasis and xenotransplantation
Naoyuki Taniguchi......... 5P
Award Lectures
AL-1 A study on the physiological functions of receptors for
the E-type and F-type prostaglandins
Yukihiko Sugimoto......... 6P
AL-2 Pharmacological analysis of integrin function: Inhibition of vascular
stenosis and identification of a novel antiplatelet substance
Hiroyuki Matsuno......... 6P
AL-3 Application of decoy strategy as a tool of gene therapy and analysis
of gene
regulation
Ryuichi Morishita......... 6P
Symposia
S1 Application and perspective of transgenic animals for pharmacological
research
Katsuhide Nishi and Masami Mishina....... 8P
S2 Pharmacology on cyclic ADP-ribose-dependent Ca2+ signaling
Haruhiro Higashida and Yasuyuki Nomura........ 9P
S3 Trends in geriatric pharmacological research and the future
Hideyo Ohshika and Shinichi Kobayashi........ 10P
S4 Molecular pharmacology in the treatment of periodontal disease in aging
society
Akira Matsumoto and Yuzo Kato........ 12P
S5 Neuropharmacological approaches to the in vivo analysis of the brain
Ryuji Takeda and Mitsuhiro Yoshioka........ 13P
S6 Animal models of Helicobacter Pylori infection for development
of therapeutic drugs
Susumu Okabe and Kazuo Watanabe........ 15P
S7 Capacitative Ca2+ entry: its function and structure
Yushi Ito and Toshihiko lijima........ 16P
S8 Recent advances in histamine research
Hiroyuki Fukui and Takehiko Watanabe........ 18P
S9 Molecular concepts for drug development
Masaaki Suzuki and Hirohei Yamamura........ 19P
S10 Molecular mechanism underlying epileptic seizures: for development
of
therapeutic drugs for treatment of resistant epilepsy
Jiro Suzuki and Masashi Sasa........ 21P
S11 Ion transporters in the heart: a new target for drug development
Haruaki Nakaya and Kenji Kitamura........ 22P
S12 Molecular cell pharmacology of blood vessels
Toshio Tanaka and Hideo Kanaide....... 23P
S13 Visualization of Ca2+ signaling and the machinery by pharmacological
studies
Masamitsu lino and Teruyuki Yanagisawa........ 25P
S14 New perspectives in pharmacological studies using positron emission
tomography
Yoshiharu Yonekura and Kazuhiko Yanai........ 26P
S15 Innovative strategies for the development of new drugs
Taku Nagao and Katsutoshi Goto........ 28P
S16 New aspects of sodium pump, endogenous ouabain and its binding globulin
Kazuya Taniguchi and Hakuo Takahashi........ 29P
S17 Clarification of pathogenetic mechanisms of respiratory deseases-to
seek new types of therapeutic drugs
Miwa Misawa and Takeshih Miyata........ 30P
S18 Progress in studies on L-DOPA
Yoshimi Misu and Ichiro Kanazawa........ 31P
S19 Target molecules of immunosuppressants in the central nervous system
Kohji Fukunaga and Naofumi Tokutomi........ 33P
Free Communications
Oral Sessions
Apoptosis .......... O-188-192
Bone and Dental Pharmacology.......... O-328-334
Cardiovascular Pharmacology
Blood Pressure / Circulation .......... O-124-128, O-193-197, O-291-295
Cardiac functions .......... O-119-123, O-248-259
Endothelium.......... O-98-102, O-172-176, O-313-317
Nitric Oxide .......... O-21-30, O-135-139, O-238-247
Vascular Smooth Muscles .......... O-103-107, O-177-181, O-198-202, O-318-322
Central Nervous System Pharmacology
Analgesia / Dependence.......... O-114-118, O-167-171
Behavioral Pharmacology .......... O31-36, O-302-307
Memory and Learning .......... O-76-81
Neurochemistry .......... O152-156, O-280-285
Neurotransmitters.......... O-37-41, O-157-161, O-308-312
Neuropharmacology .......... O53-63, O-260-264
Channels .......... O-11-20, O-215-226, O-270-279
Endocine Pharmacology.......... O-108-113
Exocrine Pharmacology.......... O-227-232
Gastrointestinal Pharmacology .......... O-64-75, O-182-187
Immunopharmacology and Inflammation.......... O-88-97, O-162-166,
O-203-214
Molecular Pharmacology......... O-140-151, O-286-290
Receptors ......... O-47-52, O-296-301
Renal Pharmacology.......... O-1-5, O-233-237
Respiratory Pharmacology.......... O-6-10
Signal Transduction......... O-42-46, O-129-134, O-265-269
Smooth muscle Pharmacology......... O-82-87
Statistics.......... O-323-327
Poster Sessions
Autonomic Nervous System Pharmacology..........P-296-309
Biochemical Pharmacology.......... P-129-152
Biogenic Active Substances.......... P-1-31
Bone and Dental Pharmacology.......... P-621-629
Cardiovascular Pharmacology
Blood Pressure and Circulation.......... P-248-295
Cardiac Function.......... P-208-247
Endothelium..........P-172-207
Vascular Smooth Muscles.......... P-351-392
Central Nervous System Pharmacology
Analgesia..........P-393-404
Behavioral Pharmacology..........P-474-503
Dependence and Tolerance..........P-405-414
Memory and Learning..........P-530-548
Neurochemistry..........P-549-566
Neuropharmacology..........P-415-473
Neurotransmitters..........P-504-529
Neurotrophic factor..........P-567
Chemotherapy..........P-685-689
Clinical Pharmacology..........P-646-656
Differentiation..........P-690
Endocrine Pharmacology..........P-630-645
Gastrointestinal Pharmacology..........P-310-350
Immunopharmacology and Inflammation..........P-657-684
Molecular Biology..........P-161-171
Molecular Pharmacology..........P-153-160
Receptors and Channels..........P-32-99
Renal Pharmacology..........P-576-586
Respiratory Pharmacology..........P-568-575
Signal Transduction..........P-100-128
Smooth Muscle Pharmacology..........P-587-620
Toxicology..........P-691-699
Author Index..........2
Subject Index ..........32
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