Jpn. J. Pharmacol. 82 (1), 82-84 (2000)

Phenytoin and Its Metabolite, 5ﾐ(4ﾐHydroxyphenyl)ﾐ5ﾐPhenylhydantoin, Show Bone Resorption in Cultured Neonatal Mouse Calvaria

Atsushi Takahashi^1,2, Kenji Onodera^1,*, Hisashi Shinoda¹ and Hideaki Mayanagi<sup>2


1</sup>Departmentof Pharmacology and ²Department of Pediatric Dentistry,
Tohoku University School of Dentistry, Sendai 980ﾐ8575, Japan
*To whom correspondence should be addressed.

Abstract: The effects of phenytoin and its major metabolite, 5ﾐ(4ﾐhydroxyphenyl)ﾐ5ﾐphenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoinﾐinduced bone loss in vivo.

Keywords: Phenytoin, Calvaria, Bone resorption