Xun Ye, Makoto Inoue and Hiroshi Ueda*
Department of Molecular Pharmacology and Neuroscience, Nagasaki University
School of Pharmaceutical Sciences,
1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
*ﾊTo whom correspondence should be addressed.
Abstract: Mice with partial ligation of the sciatic nerve exhibited
marked increase in the second phase nociceptive biting and licking behavior
following intraplantar injection of formalin. The intrathecal pretreatment
with botulinum toxin C3 dose-dependently attenuated the hyperalgesia in
the second phase. These results suggest that a small Gﾊprotein, Rho, and
its downstream mechanisms are involved in the hyperalgesia following partial
nerve injury.
Keywords: Botulinum toxin C3, Hyperalgesia, Sciatic nerve injury