Shinichi Fujita, Yuji Ikegaya*, Nobuyoshi Nishiyama and Norio Matsuki
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical
Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033,
Japan
*ﾊTo whom correspondence should be addressed.
Abstract: Pharmacological blockade of Ca2+-independent
phospholipaseﾊA2 (PLA2) is reported to disintegrate
hippocampal synaptic plasticity, which is thought to be the cellular mechanism
underlying learning and memory. Therefore, we investigated the effect of
the Ca2+-independent PLA2 inhibitor bromoenol lactone
(BEL) on spontaneous alteration behaviors of mice. When 3ﾊnmol BEL was intracerebroventricularly
injected 30ﾊmin prior to the test, the mice showed a poor alternation ratio,
compared with control animals. The data suggest that Ca2+-independent
PLA2 activity is required for spatial memory.
Keywords: Phospholipase A2, Learning and memory, Spontaneous
alternation behavior