Takao Shimazoe1, Junichi Ishida2, Miyuki Maetani1,
Tomohiro Yakabe2, Masatoshi Yamaguchi2,
Kyoko Miyasaka3, Akira Kono4, Shigenori Watanabe1
and Akihiro Funakoshi4
1Departmentﾊof Pharmacology, Graduate School of Pharmaceutical
Sciences, Kyushu University, Fukuoka 812-8582, Japan
2Departmentﾊof Analytical Chemistry, Faculty of Pharmaceutical
Sciences, Fukuoka University, Fukuoka 814-0180, Japan
3Departmentﾊof Clinical Physiology, Tokyo Metropolitan Institute
of Gerontology, Tokyo 173-0015, Japan
4NationalﾊKyushu Cancer Center, Fukuoka 811-1395, Japan
Abstract: The term for re-entrainment to a new light-dark cycle
in streptozotocin (STZ)-induced diabetic rats was significantly longer than
that in control rats. In STZ-induced diabetic rats, the same level of phase
delay in the suprachiasmatic nucleus neuronal firing rhythm was observed
in control rats after glutamate application. Therefore, 5-HT function in
the hypothalamus is thought to be decreased in STZ-induced diabetic rats.
These results suggest that postsynaptic neuronal function is still maintained
in the suprachiasmatic nucleus of STZ-induced diabetic rats. Therefore,
5-HT mechanisms may play an important role in the maintenance of this function.
Keywords: Streptozotocin, Suprachiasmatic nucleus, Entrainment
Copyrightｩ The Japanese Pharmacological Society 2000
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