Toshihiro Okamoto1,3, Kenichi Yamamura2 and Okio
Hino3,*
1ResearchﾊLaboratories, Nippon Chemiphar Co., Ltd., Saitama
341-0005, Japan
2Instituteﾊof Molecular Embryology and Genetics, Kumamoto University
School of Medicine, Kumamoto 862-0976, Japan
3Departmentﾊof Experimental Pathology, Cancer Institute, Tokyo
170-8455, Japan
*To whom correspondence should be addressed.
Abstract: Interferon-g (IFN-g)
transgenic mice expressed the IFN-g gene in the
liver and developed chronic hepatitis. The expression of cyclooxygenase
(Cox)-1 and -2 mRNA were studied in the livers of these mice. A faint band
of Cox-1 mRNA was observed in the livers of both normal and transgenic mice.
Slight expression of Cox-2 mRNA was observed in the normal mouse liver,
and this mRNA expression was induced in the transgenic mouse liver. The
present results showed the induction of Cox-2 mRNA expression in the livers
of transgenic mice with chronic hepatitis.
Keywords: Transgenic mouse, Cyclooxygenase, Liver
Copyrightｩ The Japanese Pharmacological Society 2000
[Back to TOC]