Makoto Katoh1,2, Kensuke Egashira2 and Akira Takeshita2
1DiscoveryﾊResearch Laboratory, Tanabe Seiyaku Co., Ltd.,
2-2-50, Kawagishi, Toda, Saitama 335-8505, Japan
2TheﾊDepartment of Cardiovascular Medicine, Kyushu University
Faculty of Medicine, 3-3-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Abstract: We studied the effect of chronic (7ﾊdays) angiotensinﾊII
infusion in a subpressor (200ﾊng/kg per minute) dose on angiotensinﾊII receptors
in the left ventricle in rats. Infusion of angiotensinﾊII caused an elevation
in systolic blood pressure after 3ﾊdays, usually to values of about 150ﾊmmHg,
and the increase continued during the drug administration. The number of
angiotensinﾊII typeﾊ1 and angiotensinﾊII typeﾊ2 receptors was significantly
decreased by 20-30% in the angiotensinﾊII-infused left ventricular membranes
without affecting the affinity. Thus, these data suggest that angiotensinﾊII
may regulate the number of its own receptors in rat left ventricles.
Keywords: AngiotensinﾊII, Angiotensin receptor, Rat left ventricle
Copyrightｩ The Japanese Pharmacological Society 2000
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