Atsuko Kawashimo, Takao Shimazoe*, Akiko Yoshimatsu and Shigenori Watanabe
Department of Pharmacology, Graduate School of Pharmaceutical Sciences,
Kyushu University 62, Fukuoka 812-8582, Japan
*ﾊTo whom correspondence should be addressed.
Abstract: Adenosine was intraperitoneally (i.p.) injected to
Wistar rats every 3ﾊdays with a total of 5ﾊadministrations. After a 7-day
withdrawal, the animals were challenged with methamphetamine (0.5ﾊmg/kg,
i.p.). The effect of methamphetamine on locomotor activity was significantly
potentiated by repeated adenosine pre-treatment. Moreover, methamphetamine-induced
dopamine release was also increased in the striatum. Meth-amphetamine-induced
hyperactivity and dopamine release were significantly potentiated by repeated
pre-treatment of an adenosineﾊA1 agonist, N6-cyclohexyladenosine
(0.5ﾊmg/kg, i.p.). These results suggest that the acute effect of methamphetamine
is potentiated by repeated pre-treatment of adenosine via adenosineﾊA1
receptors.
Keywords: Methamphetamine, Adenosine, AdenosineﾊA1 receptor
Copyrightｩ The Japanese Pharmacological Society 2000
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