Hideyuki Yamatoya, Masashi Sakai and Satoshi Kudo
Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi,
Tokyo 186-8650, Japan
Abstract: The effects of soybean transphosphatidylated phosphatidylserine
(SB-tPS) on cholinergic synaptic functions were investigated using cerebral
cortical synaptosomes from mice. Treatment of the synaptosomes with SB-tPS
increased high K+-induced acetylcholine (ACh) release in a bell-shaped,
dose-dependent manner without affecting ACh synthesis. SB-tPS (10 and 50ﾊmM)
also enhanced synaptosomal synthesis of sn-glycero-3-phosphocholine,
but did not affect phosphorylcholine synthesis. In contrast, the choline
synthesis was significantly reduced as SB-tPS concentration increased. The
present result that SB-tPS modified the cholinergic pathway can partly explain
its nootropic functions.
Keywords: Phosphatidylserine, Acetylcholine, Synaptosome
Copyrightｩ The Japanese Pharmacological Society 2000
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