Kozo Yao1,*, Nils Heyne2 and Hartmut Osswald2
1Drug Development Research Laboratories, Pharmaceutical Research
Institute, Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi-cho,
Sunto-gun, Shizuoka 411-8731, Japan
2Department of Pharmacology, Faculty of Medicine, University
of T歟ingen, Wilhelmstr. 56, 72074 T歟ingen, FRG
*Corresponding author.ﾊﾊFAX:+81-559-86-7430
E-mail: kozo.yao@kyowa.co.jp
Abstract: To study the possible mechanism of renoprotective effects
of adenosine A1-receptor antagonist against radiocontrast media
(RCM)-induced nephropathy, we investigated the effects of adenosine A1-receptor
antagonist on tubuloglomerular feedback (TGF) activity prior to and following
application of RCM in chronic NO-depleted rats. TGF in NO-depleted rats
was significantly enhanced compared with that in normal rats. After RCM
application, the enhanced TGF was continued. A selective adenosine A1-receptor
antagonist, KW-3902 (8-(noradamantan-3-yl)-1,3-dipropylxanthine), inhibited
the enhanced TGF. These results suggest that KW-3902 could inhibit TGF in
chronic NO-depleted rats. Renoprotective effects by adenosine antagonists
could be partly due to an inhibition of TGF via the blockade of the adenosine
A1-receptor.
Keywords: Contrast media, Adenosine, Tubuloglomerular feedback
Copyrightｩ The Japanese Pharmacological Society 2000
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