Nobuaki Matsui, Ikuko Satsuki, Yuka Morita, Keiichi Inaizumi, Kazumi
Kasajima, Reiko Kanoh, Nobuyuki Fukuishi and Masaaki Akagi*
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima
Bunri University,180 Nishihama-bouji, Yamashiro-cho, Tokushima city, Tokushima
770-8514, Japan
*Corresponding author.ﾊﾊFAX:+81-88-655-3051
E-mail: akagi@ph.bunri-u.ac.jp
Abstract: The present study was carried out to elucidate the relationship
between the generation of reactive oxygen species (ROS) and an activation
of nuclear factor (NF) kappaﾊB in a hepatic ischemia-reperfusion model.
During the ischemic period, the contents of xanthine oxidase (XOD) metabolites
and thiobarbituric acid-reactive substances were significantly increased,
and NF-kappaﾊB was activated in the liver of rats. The activation of NF-kappaﾊB
was inhibited by pretreatment of allopurinol (10-100ﾊmg/kg, i.p.) in a dose-dependent
manner. In conclusion, this suggests that the XOD-derived ROS may activate
NF-kappaﾊB during ischemia.
Keywords: Xanthine oxidase, Nuclear factor kappaﾊB, Reactive oxygen species
Copyrightｩ The Japanese Pharmacological Society 2000
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