Ak溝han Gepdiremen1,*, Selma D毟enli2, Ahmet Hacim歿t殪glu1,
Dilek Bulucu1 and Halis S殕eyman1
Departments of 1Pharmacology and 2Medical Genetics,
Atat殲k University, Medical Faculty, TR-25240 Erzurum, Turkey
*Corresponding author.ﾊﾊFAX:+90-442-2349013
E-mail: akcahan@atauni.edu.tr
Abstract: In the present study, melatonin was tested in subsequent
doses in glutamate induced neurotoxicity in cerebellar granular cell culture
of rat pups. Glutamate at 10-7ﾊM was found to induce neuronal
cell death. The dead cell score was 2.75ﾊｱﾊ0.7
in the control, while it was found to be 35.12ﾊｱﾊ1.8
in the glutamate-administered group (P<ﾊ0.0001).
Melatonin very potently blocked glutamate neurotoxicity at all doses tested,
with 10-3ﾊM, the highest dose tested, being the most effective.
Glutamate may exert a neuroprotective effect by blocking one or more steps
of the oxidation cascade in neurons and this effect may be blocked by melatonin.
Keywords: Glutamate, Melatonin, Neuroprotection
Copyrightｩ The Japanese Pharmacological Society 2000
[Back to TOC]