Den'etsu Sutoo* and Kayo Akiyama
Institute of Medical Science, University of Tsukuba, Tsukuba 305-8575, Japan
*Corresponding author. FAX: +81-298-54-9817, E-mail: dsutoo@md.tsukuba.ac.jp
Abstract: The effects of intracerebroventricular administration of calcium or magnesium on the blood pressure regulation in the brain were investigated. The systolic blood pressure in spontaneously hypertensive rats (male, 13-week-old) was decreased by calcium chloride (100 mg/rat) and increased by magnesium chloride (20, 100 or 500 mg/rat). The depressor response induced by calcium was inhibited by magnesium chloride in a dose-dependent manner. Combining these results with those previously reported, it is suggested that magnesium inhibits the ability of calcium to reduce blood pressure through calmodulin- and dopamine-dependent functions in the brain.
Keywords: Blood pressure in spontaneously hypertensive rats, Calcium/calmodulin-dependent dopamine synthesis, Magnesium
[Back to TOC]