Takehiro Hagiwara*, Sumie Satoh, Yoshio Kasai and Kiyoshi Takasuna
New Product Research Laboratories II, Daiichi Pharmaceutical Co., Ltd., 16-13, Kita-Kasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan
*Corresponding author. FAX: +81-3-5696-8607, E-mail: hagiwwjn@daiichipharm.co.jp
Abstract: We examined the effects of ten fluoroquinolone antibacterial agents, levofloxacin, sitafloxacin, trovafloxacin, ciprofloxacin, gemifloxacin, tosufloxacin, gatifloxacin, grepafloxacin, moxifloxacin and sparfloxacin, on action potentials recorded from guinea pig ventricular myocardia. Sparfloxacin prolonged action potential duration (APD) by about 8% at 10 mM and 41% at 100 mM. Gatifloxacin, grepafloxacin and moxifloxacin also prolonged APD at 100 mM by about 13%, 24% and 25%, respectively. In contrast, levofloxacin, sitafloxacin, trovafloxacin, ciprofloxacin, gemifloxacin and tosufloxacin had little or no APD-prolonging effect at concentrations as high as 100 mM. These findings suggest that there are differences in potency to prolong QT interval among the fluoroquinolones.
Keywords: Action potential duration, Fluoroquinolone, QT prolongation
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