Yoshimasa Yamaguchi*, Masaya Higashi, Toshiyuki Matsuno and
Seiichiro Kawashima
Research Laboratory, Zenyaku Kogyo Co., Ltd., 2-33-7 Ohizumi-machi,
Nerima-ku, Tokyo 178-0062, Japan
*Corresponding author. FAX: +81-3-3922-5065, E-mail: Yoshimasa_Yamaguchi@mail.zenyaku.co.jp
Abstract: Effects of ZSET845 (3,3-dibenzylimidazo[1,2-a]pyridin-2-(3H)-one),
a newly synthesized cognitive enhancer, and donepezil and tacrine
on the scopolamine-induced cognitive deficits in rats were examined
in passive avoidance and radial-arm maze tasks. ZSET845 (0.01
mg/kg) showed a greater ameliorative effect than donepezil (0.1
mg/kg) or tacrine (1 mg/kg) in the passive avoidance task. In
the radial-arm maze task, ZSET845 (0.1 mg/kg) also showed a greater
effect than donepezil (10 mg/kg) or tacrine (10 mg/kg). ZSET845
induced an increase in the choline acetyltransferase (ChAT) activity
in the hippocampus, suggesting that the ameliorative effects of
ZSET845 are related to the increase in the ChAT activity in the
hippocampus.
Keywords: Passive avoidance, Radial-arm maze, Choline acetyltransferase
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