Nobuyuki Kishibayashi and Akira Karasawa
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411, Japan
Abstract:
We examined the effects of KW-5092 ({1-[2-[[[5-(piperidinomethyl)-2-furanyl]methyl]- amino]ethyl]-2-imidazolidinylidene} propanedinitrile fumarate). a novel gastroprokinetic agent, on gastric mucosal blood flow (GMBF) in anesthetized rats. Intravenous infusion of KW-5092 (0.1 mg/kg/min for 30 min), which did not affect the basal GMBF, reversed the norepinephrine (1 microg/kg/min, i.v. infusion for 30 min)-induced decline of CMBF in the corpus and the antrum. The improvement by KW-5092 of the GMBF was abolished by atropine (0.1 mg/kg/min, i.v. infusion for 30 min). These results suggest that KW-5092, via cholinergic activation, could counteract the decline of GMBF induced by adrenergic activation
Keywords: KW-5092, Gastric mucosal blood flow, Norepinephrine