Katsuhiro Fujimoto (1), Keiko Yamamura (2,*), Tetsuo Hayashi (2), Takashi Osada (2) and Tsunehisa Sakurai (1)
(1) First Department of Surgery, (2) Department of Hospital Pharmacy, Nagoya University School of Medicine, Tsuruma-cho, Showa-ku, Nagoya 466, Japan
Abstract: The susceptibility of Dacron grafts to infection is compared with Dacron grafts applied with levofloxacin-bonded albumin (LVFX-ALB) following the inoculation of 10-7 cells Staphylococcus aureus in rats. Staphylococcus epidermidis was inoculated in the same manner. While the control grafts were infected at the time of removal, the LVFX-ALB Dacron grafts resisted infection, thus demonstrating their effectiveness.
Keywords: Levofloxacin, Albumin, Graft infection