Shusheng Tai, Hirofumi Kai, Yoichiro Isohama, Kazuo Takahama and Takeshi Miyata (*)
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862, Japan
(*) To whom correspondence should be addressed.
Abstract: We investigated the effect of leukotriene D4 (LTD4) on tracheal mucociliary transport in quails. Topical application of LTD4 (0.2 - 2 ng) to tracheal mucosa dose-dependently increased mucociliary transport velocity (MCTV) in 5 or 10 min after application. Forty minutes after application of 2 ng of LTD4, MCTV was decreased to about 84% of that in the control group. Both the transient increase and the subsequent decrease induced by 2 ng of LTD4 were blocked by ONO-1078 (Pranlukast: 4-oxo-8-[4-(4-phenylbutoxy)-benzoylamino]- 2-(tetrazol-5-yl)-4H-1-benzopyran) (0.03 - 3 mg/kg, i.m.), a specific leukotriene antagonist. These results suggest that LTD4 possesses a biphasic effect on tracheal mucociliary transport through leukotriene receptors.
Keywords:
Tracheal mucociliary transport, Leukotriene D4, ONO-1078