Kazuo Umemura (1), Koichiro Wada (1,#), Yoshinari Suzuki (2), Hiroshi Nishiyama (1) and Mitsuyoshi Nakashima (1)
(1) Department of Pharmacology and (2) Hospital Pharmacy, Hamamatsu University School of Medicine, Hamamatsu 431-31, Japan (#) Present address: Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago 683, Japan
Abstract: The aim of this study was to investigate if prostaglandin (PG) metabolism is altered by angiotensin-converting enzyme (ACE) inhibitors as determined in the broncho-alveolar lavage fluid (BALF) of the guinea pig. Enalapril or imidapril was orally administered once a day for 2 weeks to Hartley male guinea pigs. Twenty-four hours after the last treatment, BALF was collected and the concentrations of PGI2, thromboxane A2 (TXA2) and PGE2 were measured by enzyme immunoassay. Enalapril significantly (P < 0.05) increased the TXA2 content, which was inhibited by indomethacin treatment and significantly (P < 0.05) decreased the PGI2 content. Imidapril, however, did not affect TXA2 or PGI2 generation. These findings suggest that altered PG metabolism may be associated with coughing as a side effect of enalapril.
Keywords:
Imidapril, Angiotensin-converting enzyme inhibitor, Broncho-alveolar lavage fluid,
Thromboxane A2, Prostacyclin