Katsuo Kamata, Tsuyoshi Hayashi and Fujio Umeda
Department of Physiology and Morphology, Institute of Medicinal Chemistry,
Hoshi University, Shinagawa-ku, Tokyo 142, Japan
Abstract: We recently reported that cyclopiazonic acid (CPA)
releases a novel endothelium-derived relaxing factor that is not prostacyclin,
nitric oxide or endothelium-derived hyperpolarizing factor in rat mesenteric
arterial bed. The acetylcholine-induced vasodilatation of the isolated mesenteric
bed in spontaneously hypertensive rats (SHR) was not different from that
in Wistar Kyoto rats (WKY), but it was significantly smaller in streptozotocin
(STZ)-induced diabetic rats than in age-matched controls. The CPA-induced
vasodilatation was not affected in SHR or in STZ-induced diabetic rats.
These results suggest that the CPA-induced endothelium-dependent vasodilatation
is resistant to the effects of diabetes.
Keywords: Cyclopiazonic acid, Diabetes, Endothelium-derived relaxing
factor