Jpn. J. Pharmacol. 74 (2), 217-220 (1997)
Enhancement by Morphine of Radiographic Contrast Media-Induced Histamine
Release in Rat Peritoneal Mast Cells
Masanori Sueyasu, Chiharu Komasu, Tomoko Hara, Koujiro Futagami, Yasufumi
Kataoka and Ryozo Oishi (*)
Department of Hospital Pharmacy. Faculty of Medicine, Kyushu University,
Fukuoka 812-82, Japan
(*) To whom correspondence should be addressed.
Abstract: The intravascular application of radiographic contrast
media causes hypersensitivity reactions, in which histamine release may
play a major role. We examined the interaction between contrast medium and
morphine. Among the four nonionic contrast media examined, iopamidol showed
the most marked histamine release from rat peritoneal mast cells in vitro.
Although iopamidol and morphine themselves did not induce histamine release
at concentrations up to 65 mgI/ml and 3 mM, respectively, their combination
resulted in a significant histamine release. These findings suggest that
patients with exposure to medicines that induce histamine release may have
a higher incidence and severity of hypersensitivity reactions to radiographic
contrast media.
Keywords: Radiographic contrast media, Morphine, Histamine release
Copyright© The Japanese Pharmacological Society 1997
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