Takumi Kumamoto, Akihiko Matsuda, Mikiko Kataoka and Yukifumi Kokuba
Development Laboratories, Research and Development Division, Nippon Hoechst
Marion Roussel Ltd, Shiga 520-23, Japan
Abstract: To clarify the mode of action of aminosalicylates,
which are generally used as therapeutic agents for ulcerative colitis, we
investigated the effect of some of the aminosalicylates on lipid peroxidation
in the large intestinal mucosa after mesenteric ischemia/reperfusion in
the rat. Lipid peroxidation was assessed by measuring the level of thiobarbituric-acid-reactive
substances. It was found that aminosalicylates dose-dependently inhibited
the elevation of the level of thiobarbituric-acid-reactive substances in
the large intestinal mucosa after ischemia/reperfusion. This effect may
partly contribute to the therapeutic actions of aminosalicylates in ulcerative
colitis.
Keywords: Lipid peroxidation, Ischemia/reperfusion, Large intestinal
mucosa