Masayoshi Furushiro, Satoru Suzuki, Yoshiyuki Shishido, Masashi Sakai,
Hideyuki Yamatoya,Satoshi Kudo, Shusuke Hashimoto and Teruo Yokokura
Yakult Central Institute for Microbiological Research, 1796, Yaho, Kunitachi,
Tokyo 186, Japan
Abstract: Soybean lecithin transphosphatidylated phosphatidylserine
(SB-tPS) was investigated for its effect on the impaired learning of a passive
avoidance task by mice induced by scopolamine or cycloheximide. SB-tPS (240,
360, 480 mg/kg) administered orally significantly prolonged the step-through
latency shortened by scopolamine. SB-tPS (240 mg/kg) administered orally
also prolonged the step-through latency shortened by cycloheximide. These
results suggest that the effect of SB-tPS on the impaired learning behavior
may be related not only to the cholinergic system but also the serotonergic
system.
Keywords: Phosphatidylserine, Passive avoidance, Scopolamine