Toshihiro Okamoto (1), Masami Furuya (1), Tomio Yamakawa (1), Ken-ichi
Yamamura (2) and Okio Hino (3,*)
(1) Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama 341, Japan
(2) Institute of Molecular Embryology and Genetics, Kumamoto University
School of Medicine, Kumamoto 862, Japan
(3) Department of Experimental Pathology, Cancer Institute, 1-37-1 Kami-ikebukuro,
Toshima-ku, Tokyo 170, Japan
(*) To whom correspondence should be addressed.
Abstract: Previously we reported the induction of tumor necrosis
factor (TNF)-alpha mRNA in the liver of interferon (IFN)-gamma transgenic
mouse, which might be the result of IFN-gamma gene expression. In the present
study, IFN-gamma mRNA was induced in the liver, kidney and lung. TNF-alpha
mRNA was, however, induced in the liver and kidney, but not in the lung.
Induction of interleukin (IL)-2 and IL-1beta mRNA was lacking in any of
these organs. The present result showed the induction of TNF-alpha mRNA
expression in the kidney of transgenic mouse.
Keywords: Transgenic mouse, Interferon, Tumor necrosis factor