Toshihiko Kaise, Yukino Akamatsu and Kenji Ohmori
Drug Development Research Laboratories, Pharmaceutical Research Institute,
Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Sunto-gun,
Shizuoka 411, Japan
Abstract: We have investigated the effect of oxatomide, an antiallergic
agent, on experimental allergic rhinitis in sensitized guinea pigs. Oxatomide
(1 and 10 mg/kg, p.o.) significantly inhibited the sneeze response and nasal
rubbing after antigen challenge. Oxatomide (10 and 30 mg/kg) reduced the
increase in nasal vascular permeability induced by the antigen-antibody
reaction. The decreases in nasal cavity volume caused by nasal mucosal swelling
10 min, 30 min and 6 hr after antigen challenge were significantly inhibited
by oxatomide (30 mg/kg). These results indicate that oxatomide inhibits
the experimental allergic rhinitis in guinea pigs.
Keywords: Oxatomide, Experimental allergic rhinitis