Toshihiro Okamoto (1), Tadashi Kobayashi (1), Naoki Tsuzuike (2) and
Kaoru Hara (1)
(1) Research Laboratories, Nippon Chemiphar Co., Ltd., 1-22 Hikokawato,
Misato, Saitama 341-0005, Japan
(2) Zeria Pharmaceutical Co., Ltd., Konan-Machi, Ohsato-gun, Saitama 360-0111,
Japan
Abstract: The objective of the present study was to determine
the effects of concanavalin A (Con A) administration on the interleukin
1beta converting enzyme (ICE) activity and CPP32-like activity in mouse
liver. Treatment with Con A (0.2 mg/mouse, i.v.) caused an elevated plasma
alanine aminotransferase (ALT) level at 8 hr after Con A injection. ICE
activity was decreased at 8 and 24 hr after Con A treatment. In contrast,
CPP32-like activity was increased at 24 hr after Con A injection. Since
CPP32-like activity was induced after ALT had increased, the induction of
CPP32-like activity may not be involved in Con A-induced hepatitis.
Keywords: Concanavalin A, Interleukin 1beta converting enzyme, CPP32