Toshiki Takagi, Peter W. Tsao, Ryuichi Totsuka, Tatsuo Suzuki, Takashi
Murata and Isao Takata
Tanabe Seiyaku Co., Ltd., Discovery Research Laboratory, 3-16-89 Kashima,
Yodogawa-ku, Osaka 532-8505, Japan
Abstract: This study demonstrated the decrease of bone mineral
density (BMD) in the type II collagen (CII)-induced arthritis (CIA) model
in rats and the relationship between BMD and paw edema and the effect of
dexamethasone-21-phosphate (DEX). The paw swelling occurred on Day 10 and
reached its peak on Day 18 after CII injection. BMD in the CII-injected
group is lower than that in the control group. BMD in the proximal and distal
regions of the femur largely decreased in comparison with that of the middle
region. The oral administration of DEX (0.1 mg/kg) inhibited the swelling
and decrease of BMD in all three regions of the femur.
Keywords: Collagen-induced arthritis, Bone mineral density, Dexamethasone