Keiji Nishida, Yoshiji Ohta and Isao Ishiguro
Department of Biochemistry, School of Medicine, Fujita Health University,
Toyoake, Aichi 470-1192, Japan
Abstract: We examined whether the increasing action of teprenone
(TP) on mucus synthesis and content in rat gastric mucosa is related to
nitric oxide (NO) formation via NO synthase (NOS) in the tissue. TP (200
mg/kg)-induced increases in levels of gastric mucosal hexosamine and adherent
mucus were inhibited with decreased gastric mucosal NOS activity and nitrite/nitrate
concentration by co-administration of NG-monomethyl L-arginine
(100 mg/kg), a NOS inhibitor, but not its D-isomer. These results suggest
that TP exerts an increasing action on gastric mucus synthesis and content
possibly under the condition of maintained NO production via NOS in gastric
mucosal tissues, although the precise mechanisms for the action of TP is
still unclear.
Keywords: Teprenone, Gastric mucus, Nitric oxide synthase