Keiichi Musoh, Kayoko Kawamura, Isao Miyake, Shino Shimada, Tetsuo Ohashi
(*), Yuji Iwanaga, Kouji Morikawa and Hideo Kato
Research and Development Division, Hokuriku Seiyaku Co., Ltd., 1-1 Inokuchi
37, Katsuyama, Fukui 911-8555, Japan
(*) To whom correspondence should be addressed.
Abstract: The objective of the present study was to determine
the action duration of tulobuterol tape within a 24-hr period in conscious
guinea pigs. The bronchoconstriction induced by histamine-inhalation was
significantly inhibited by tulobuterol tape in comparison with its placebo
tape 8 and 12 hr after binding, and the inhibitory rate was 50 +/- 11% and
35 +/- 13%, respectively. Twenty-four hours after binding, the inhibitory
effect of tulobuterol tape gradually diminished, but the inhibitory rate
was maintained at 30+/-14%. These results suggest that tulobuterol tape
has a long lasting bronchodilatory action.
Keywords: Tulobuterol tape, beta2 stimulant, A patch formulation