Masako Okazaki, Mayumi Tsuji, Yukako Yamazaki, Yuko Kanda, Shinichi Iwai
and Katsuji Oguchi
Department of Pharmacology, School of Medicine, Showa University, Hatanodai,
Shinagawa-ku, Tokyo 142-8555, Japan
Abstract: The effects of Sasa senanensis Rehder extract (SE) by alkaline
hydrolysis on histamine release from rat peritoneal exudate cells (PECs)
were examined. Preincubation with SE for 5 min suppressed calcium-ionophore
A23187-induced histamine release in a concentration-dependent manner. A23187
evoked a quick increase in cytoplasmic free calcium ([Ca2+]i)
levels in the presence of extracellular calcium. Preincubation with SE also
had an inhibitory effect on calcium influx increases induced by A23187.
These results indicate that SE prevents degranulation from rat PECs by inhibiting
[Ca2+]i
level elevation.
Keywords: Degranulation, Bamboo grass leaf extract, Cytoplasmic free
calcium