Michitaka Shichijo (1), Yasuo Shimizu (2), Kenju Hiramatsu (2), Michinori
Togawa (1), Naoki Inagaki (1), Kenzo Takagi (2) and Hiroichi Nagai (1,*)
(1) Department of Pharmacology, Gifu Pharmaceutical University, Gifu
502-8585, Japan
(2) Department of Second Internal Medicine, Nagoya University School of
Medicine, Nagoya 466-8560, Japan
(*) To whom correspondence should be addressed.
Abstract: The effect of suplatast tosilate (IPD-1151T), which
is known to suppress interleukin (IL)-4 release from T cells, on the release
of IL-4 and IL-13 from human peripheral basophils was investigated. Basophils
were obtained from 16 mite-sensitive atopic asthmatic patients. IPD-1151T
clearly inhibited the antigen-induced release of IL-13 but not IL-4. These
results suggest that IPD-1151T possesses different activity for the regulation
of cytokine release in basophils and T cells.
Keywords: IPD-1151T (suplatast tosilate), Basophil, Interleukin-13