Nami Ohyama (1) and Shizuyo Yamaguchi (2,*)
Departments of (1) Dental Anesthesiology and (2) Pharmacology, School
of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama
230-8501, Japan
(*) To whom correspondence should be addressed.
Abstract: We investigated the dose-response effects of phenylephrine
and antagonistic effects of prazosin on axial movement of the rat incisor
and arterial blood pressure. Phenylephrine caused a temporal extrusive tooth
movement and an increase in blood pressure at all doses. With increasing
phenylephrine doses, the maximum extrusive tooth movement and maximum increase
in blood pressure were enhanced. The maximum extrusive tooth movement and
increase in blood pressure induced by phenylephrine were markedly suppressed
after pretreatment with prazosin. These results suggested that extrusive
tooth movement is closely related to the rise in blood pressure due to stimulation
of vascular alpha1-receptors.
Keywords: Phenylephrine, Prazosin, Tooth movement