Satoru Suzuki, Masayoshi Furushiro, Masatoshi Takahashi, Masashi Sakai*
and Satoshi Kudo
Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi,
Tokyo 186 - 8650, Japan
* To whom correspondence should be addressed.
Abstract: Mongolian gerbils orally administered with soybean
lecithin transphosphatidylated phosphatidylserine (SB-tPS, 240 mg/kg) for
5 days were subjected to cerebral ischemia by bilateral common carotid artery
occlusion. The pyramidal cell damage of the hippocampal CA1 subfield was
classified into 4 grades according to the proportion of damaged neurons
on the tenth day after the ischemic treatment. The damage score of the SB-tPS
group was statistically less than that of the control group. This suggests
that the pre-administration of SB-tPS may relieve the delayed neuronal cell
death caused by cerebral ischemia.
Keywords: Phosphatidylserine, Oral administration, Cerebral ischemia