Jpn. J. Pharmacol. 81 (4), 388 - 392 (1999)

Structure and Sequence of the Mouse V1a and V1b Vasopressin
Receptor Genes

Shintaro Kikuchi^1,2, Akito Tanoue¹, Nobuhito Goda¹, Nobutake Matsuo² and Gozoh Tsujimoto^1,*


¹Department of Molecular, Cell Pharmacology, National Children's Medical Research Center, 3 - 35 - 31 Taishido, Setagaya-ku, Tokyo 154 - 8509, Japan
²Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160 - 8582, Japan
* To whom correspondence should be addressed.

Abstract: The structural organization and 5'-flanking region of the mouse V1a and V1b vasopressin receptor genes were determined. The mouse V1a receptor gene was located within an 8-kb XbaI fragment, and the mouse V1b receptor gene was located within a 14-kb EcoRV fragment. Both genes were comprised of two coding exons that were separated by a 2.3-kb and a 8.0-kb intron, respectively, located before the respective seventh transmembrane domain of the receptor sequence. The availability of these genes would allow us to study the functional role of V1a and V1b receptors by disrupting the gene in mice.

Keywords: V1a vasopressin receptor gene (mouse), V1b vasopressin receptor gene (mouse)