Kenji Onodera1,*, Ko Zushida2 and Junzo Kamei2
1Department of Dental Pharmacology, Okayama University Dental
School, Sikata-cho, Okayama 700-8525, Japan
2Department of Pathophysiology & Therapeutics, Faculty of
Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501,
Japan
*Corresponding author. FAX: +81-86-235-6664
E-mail: onoderak@md.okayama-u.ac.jp
Abstract: The antinociceptive effect of vitamin K2 (menatetrenone)
in diabetic mice was examined using a tail-pressure test. Intraperitoneal
injection of menatetrenone (10-100 mg/kg) produced a dose-dependent increase
in the nociceptive threshold in diabetic mice. There was no significant
difference between non-diabetic and diabetic mice in the menatetrenone-induced
changes in the nociceptive threshold. The results suggest the therapeutical
usefulness of menatetrenone for treating painful diabetic neuropathy and
osteoporosis.
Keywords: Vitamin K2 (menatetrenone), Antinociception, Painful
diabetic neuropathy
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