Review

207-213
-Current Perspective-
(1S,2R)-1-Phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide(PPDC), a New Class of NMDA-Receptor Antagonist: Molecular Design by a Novel Conformational Restriction Strategy
Satoshi Shuto, Kiyonori Yoshii and Akira Matsuda

Full Papers

214-226
Molecular Mechanisms for a₂-Adrenoceptor-Mediated Regulation of Synoviocyte Populations
Katsuyuki Mishima, Hitomi Otani, Takatoshi Tanabe, Hiroshi Kawasaki, Akihiro Oshiro, Naoaki Saito, Ryokei Ogawa and Chiyoko Inagaki

227-233
Protective Effect of Ninjin-yoei-to on Damage to Isolated Hepatocytes Following Transient Exposure to tert-Butyl Hydroperoxide
Fusako Takayama, Toru Egashira and Yasumitsu Yamanaka

234-240
Vasorelaxant Effects of Pramanicin, an Anti-fungal Agent: Selective Action on Endothelial Cells
Chiu-Yin Kwan, Paul H.M. Harrison, Petra A. Duspara and Edwin E. Daniel

241-249
The Influence of Phosphodiesterase Inhibitor, Rolipram, on Hemodynamics in Lipopolysaccharide-Treated Rats
Prasannajit Dutta, Deanne E. Ryan and Reza Tabrizchi

250-259
Role of Mast Cells in Antigen-Induced Airway Inflammation and Bronchial Hyperresponsiveness in Rats
Naoki Kawada, Hiroyuki Tanaka, Toshiaki Takizawa, Takatoshi Yamada, Yoshimasa Takahashi, Taisei Masuda, Naoki Inagaki and Hiroichi Nagai

260-270
State-Dependent Inhibition of L-type Ca²⁺ Channels in A7r5 Cells by Cilnidipine and Its Derivatives
Ryuji Uchida, Jun Yamazaki, Satoru Ozeki and Kenji Kitamura

271-277
Na⁺/H⁺ Exchange Inhibitor SM-20220 Improves Endothelial Dysfunction Induced by Ischemia-Reperfusion
Naotsugu Horikawa, Yoshikazu Kuribayashi, Natsuko Itoh, Mizue Nishioka, Kazuki Matsui, Nobuko Kawamura and Naohito Ohashi

278-281
Phosphate Stimulates Differentiation and Mineralization of the Chondroprogenitor Clone ATDC5
Takashi Fujita, Toru Meguro, Nobuo Izumo, Chigusa Yasutomi, Ryo Fukuyama, Hiromichi Nakamuta and Masao Koida

282-290
TRK-820, a Selective k-Opioid Agonist, Produces Potent Antinociception in Cynomolgus Monkeys
Takashi Endoh, Atsushi Tajima, Naoki Izumimoto, Tomohiko Suzuki, Akiyoshi Saitoh, Tsutomu Suzuki, Minoru Narita, Junzo Kamei, Leon F. Tseng, Hirokazu Mizoguchi and Hiroshi Nagase

291-298
The Properties of Carbachol-Activated Nonselective Cation Channels at the Single Channel Level in Guinea Pig Gastric Myocytes
Tong Mook Kang, Young Chul Kim, Jae Hoon Sim, Jong Chul Rhee, Sung Joon Kim, Dae Yong Uhm, Insuk So and Ki Whan Kim

299-305
Comparative Study on the Vasorelaxant Effects of Three Harmala Alkaloids In Vitro
Chuen-Chao Shi, Jyh-Fei Liao and Chieh-Fu Chen

306-312
Involvement of Tyrosine Hydroxylase Upregulation in Cyclosporine-Induced Hypertension
Hiromi Shimizu, Toshio Kumai and Shinichi Kobayashi

313-321
Blood Pressure and Heart Rate Are Increased by AF-DX 116, a Selective M₂ Antagonist, in Autonomic Imbalanced and Hypotensive Rats Caused by Repeated Cold Stress
Taeko Hata, Eiji Itoh, Yoshinori Funakami, Katsushi Ishida and Shuji Uchida

322-326
Presence of Aldose Reductase Inhibitors in Tea Leaves
Itaru Sakai, Shun-ichiro Izumi, Takayo Murano, Shinji Okuwaki, Tsunehisa Makino and Takashi Suzuki

Short Communications

327-330
Comparison of Noradrenergic and Serotonergic Antidepressants in Reducing Immobility Time in the Tail Suspension Test
Jun Fujishiro, Taiichiro Imanishi, Jun Baba and Kenji Kosaka

331-334
Utilization of Telemetry System to Assess the Cardiovascular Profile of AH-1058, a New Cardioselective Ca²⁺ Channel Blocker, in Conscious Dogs
Akira Takahara, Hideki Dohmoto, Ryota Yoshimoto, Atsushi Sugiyama and Keitaro Hashimoto

Rapid Communication

335-337
Antinociceptive Effect of Vitamin K₂ (Menatetrenone) in Diabetic Mice
Kenji Onodera, Ko Zushida and Junzo Kamei